Tuning the Properties of Polymer Capsules for Cellular Interactions

H Sun; J Cui; Y Ju; X Chen; EHH Wong; J Tran; GG Qiao; F Caruso

Journal article

Tuning the Properties of Polymer Capsules for Cellular Interactions

H Sun, J Cui, Y Ju, X Chen, EHH Wong, J Tran, GG Qiao, F Caruso

Bioconjugate Chemistry | AMER CHEMICAL SOC | Published : 2017

DOI: 10.1021/acs.bioconjchem.7b00168

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Abstract

Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, we report the preparation of various polymer capsules with different compositions and properties via atom transfer radical polymerization mediated continuous assembly of polymers (CAPATRP), where the cellular interactions of these capsules, particularly fouling and specific targeting, are examined by flow cytometry and deconvolution microscopy. Acrylated eight-arm poly(ethylene glycol) (8-PEG) and poly(N-(2-hydroxypropyl)-methacrylamide) (PHPMA) as well as methacrylated hyaluronic acid (HA), poly(glutamic acid) (PGA), and poly(methacrylic acid) (PMA) are used as m..

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University of Melbourne Researchers

Yi David Ju Author

Greg Qiao Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (grant no. CE140100036), and the ARC under the Australian Laureate Fellowship (grant no. FL120100030, F.C.), the Future Fellowship (grant no. FT110100411, G.G.Q), the Discovery Project (grant nos. DP1094147 and DP130101846, F.C., and G.G.Q), and the Super Science Fellowship (grant no. FS110200025, F.C. and G.G.Q) schemes. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We acknowledge Dr. Biao Kong, Dr. Christina Cortez-Jugo, Dr. Junling Guo, and Tomoya Suma (the University of Melbourne) for helpful discussions.